Polynucleotides Treatment: Which Areas Can Be Treated?

Polynucleotide treatments are gaining attention for their ability to support the skin’s natural repair and hydration processes.

Rather than simply adding volume like some injectables, polynucleotides work at a cellular level to encourage collagen and elastin production and help improve skin quality over time. This guide explains where on the face and body these treatments are commonly used and what that might mean for you.

How Polynucleotide Treatments Support Skin Health

Polynucleotides are purified DNA fragments that help activate fibroblasts — the cells responsible for producing collagen and elastin, essential proteins for skin elasticity and firmness. They also support hydration and have calming properties that may help with irritation or redness.

Positive research has shown improvements in skin texture, fine lines and signs of ageing when polynucleotides are used in regenerative treatments.

Common Areas Treated With Polynucleotides

Polynucleotide therapy can be used in many places where skin quality and hydration benefit from regeneration rather than just volume enhancement. Below are the areas that patients often explore:

1. Face

The face is the most frequently treated area, with polynucleotides used to improve overall skin quality and address specific concerns:

• Under eyes: Helps improve fine lines, crepey skin and dark circles by supporting collagen production.
• Cheeks and mid face: Aims to enhance hydration, improve texture and contribute to a refreshed appearance.
• Forehead and around the mouth: May help reduce the appearance of early lines and improve overall smoothness.

2. Neck and Décolletage

The neck and chest are common areas where skin can show signs of ageing due to sun exposure and natural loss of elasticity over time. Polynucleotides help encourage tissue repair and hydration in these regions.

3. Hands

Hands often show early signs of skin thinning and crepiness. Polynucleotide treatment may support improved texture and hydration, making hands look fresher and feel softer.

4. Scalp

An emerging application is using polynucleotides to support scalp health. This can help nourish hair follicles and may contribute to hair density improvements in some individuals.

5. Scars and Stretch Marks

Because polynucleotides encourage cellular repair, they can be considered for areas with scarring or stretch marks, where improving the skin’s regenerative environment may support skin tightening, texture, and overall appearance.

What Happens During Treatment?

Each treatment session typically involves a consultation to discuss your skin concerns and review your goals. A practitioner then administers very fine injections into the skin of the target area. Most people describe the sensation as mild and short-lived. After treatment, there may be some temporary redness or small bumps where the injections were placed.

Practical Tips for Treatment and Aftercare

• Consultation: Start with a friendly chat about your skin goals so the practitioner can tailor a plan that feels right for you.
• Sun protection: Use SPF daily to protect regenerating skin, especially after treatments.
• Hydration: Keeping skin hydrated and well moisturised can support the natural healing process.
• Activity: Avoid heat-intensive activities, saunas or steam rooms for 24–48 hours after treatment.

Thinking About Polynucleotides in Chelsea?

If you’re interested in exploring where polynucleotide treatment might help your skin — whether the delicate under eye area, neck lines, hands or other regions — a consultation with Advanced Aesthetics Clinic in Chelsea can help you understand your options.

At Sadaf Jaffari Clinic, we aim to support you with clear information and personalised advice so you feel confident about your choices, and you can book an appointment when you feel ready.