How Often Should You Have Polynucleotides Treatment?

Polynucleotides in Chelsea — A Patient-Friendly Guide

If you’re curious about polynucleotides as a way to support your skin’s natural repair and hydration processes, one of the most common questions people ask is: how often should I have this treatment?

Understanding the typical treatment schedule can help you make an informed choice about what to expect.

This clear, patient-focused guide explains typical session spacing, maintenance schedules, and practical tips to help you navigate your polynucleotide journey.

What Polynucleotide Treatment Does for Skin

Polynucleotide therapy involves injections of purified DNA fragments that help stimulate fibroblasts — the cells that support collagen and elastin production. This process may improve skin hydration, texture, elasticity, and skin tightening over time, rather than simply adding volume like traditional filler.

Clinical observations suggest that polynucleotide injections can lead to improvements in fine lines, skin thickness and overall quality. In a small study involving facial injections, patients showed noticeable improvements in skin texture and wrinkles after a series of treatments, with minimal adverse reactions.

Typical Treatment Schedule: How Often?

Before discussing frequency, it’s important to remember that how often you have polynucleotide treatment depends on your skin goals, current skin condition and lifestyle.

Here’s how schedules are commonly structured:

1. Initial Course of Sessions

Most plans involve an initial course of multiple sessions spaced a few weeks apart. This helps build the regenerating effects gradually.

Typical recommendations include:

• 4-6 sessions recommended for best results: First 2 sessions spaced one week apart, followed by a 2-week break, then any remaining sessions 2 weeks apart.

Many clinics share that spacing sessions in this way gives your skin time to respond and adapt between treatments.

A single session may offer subtle improvement, but completing this initial series generally gives more noticeable, sustained results.

2. Maintenance Sessions

Once you have completed the initial course, many people choose periodic top-ups to sustain the effects.
Common approaches include:

• One maintenance session every 6–12 months to keep collagen and elastin support active.
• Some plans suggest maintenance every 6–9 months, depending on how your skin responds and your personal goals.

This is similar to how many skin regenerative treatments are maintained — through periodic reinforcement rather than a single, ongoing course.

Why Multiple Sessions Matter

Polynucleotides don’t act instantly like some cosmetic injectables; their effect builds as the product interacts with your skin’s natural processes, rather than providing immediate results like treatments such as HydraFacial. Improvements often develop over weeks or months — especially as collagen production and hydration increase gradually.

Completing a series of sessions spaced appropriately gives your skin time to respond, and maintenance top-ups help preserve results as collagen turnover naturally slows with age.

Practical Tips for Scheduling

Here are some friendly pointers to help you plan your treatment timeline:

• Plan: Book spaced appointments to keep your schedule consistent and easy to manage.
• Track progress: Take photos before and after sessions to notice subtle changes over time.
• Combine with good skincare: Using effective moisturisers and sun protection can help prolong results between sessions.

Thinking About Polynucleotides in Chelsea?

If you’re considering polynucleotide treatment and want clarity on how often you might need sessions for your skin concerns, a consultation can help tailor a plan to you.

At Sadaf Jaffari Clinic, we aim to support you with clear information and personalised advice so you feel confident about your choices and book an appointment with confidence.